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Results: 4
The COSI trial
Camilla Rosan, Kim Alyousefi-van Dijk, Zoe Darwin, Daphne Babalis, Victoria Cornelius, Rachel Phillips, Lani Richards, Hannah Wright, Steve Pilling, Pasco Fearon, Elena Pizzo, Peter Fonagy
Apr 13, 2023
Background
Perinatal mental health difficulties affect up to 27% of birthing parents during pregnancy and the first postnatal year, and if untreated are associated with difficulties in bonding and long-term adverse...
Child Development randomised controlled trial Perinatal mental health Child Attachment Circle Of Security-parenting Parent-infant Bonding Humans Single-Blind Method Parenting Community Mental Health Services Pregnancy Quality of life Child Cost-Benefit Analysis England Female Multicenter Studies as Topic Randomized Controlled Trials as Topic
Published by: Trials
Maternal immunisation against Group B Streptococcus
Simon R Procter, Bronner P Gonçalves, Proma Paul, Jaya Chandna, Farah Seedat, Artemis Koukounari, Raymond Hutubessy, Caroline Trotter, Joy E Lawn, Mark Jit
Apr 14, 2023
Background
Group B Streptococcus (GBS) can cause invasive disease (iGBS) in young infants, typically presenting as sepsis or meningitis, and is also associated with stillbirth and preterm birth. GBS vaccines are under...
Humans Streptococcus Agalactiae Streptococcal Infections premature birth vaccines Immunization Vaccination Bayes Theorem Pregnancy Quality of life Infant Infant Newborn Cost-Benefit Analysis Female Stillbirth
Published by: PLoS Medicine
Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR.
Jake R Thomas, Anna Appios, Emily F Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W Hanna, Naomi McGovern
Apr 17, 2023
The earliest macrophages are generated during embryonic development from erythro-myeloid progenitors (EMPs) via primitive haematopoiesis. Although this process is thought to be spatially restricted to the yolk sac in the mouse...
MACROPHAGES Placenta Animals Humans Mice HLA-DR Antigens Hematopoiesis Embryonic Development Pregnancy Female
Published by: Nature Communications
Spatial multiomics map of trophoblast development in early pregnancy.
Anna Arutyunyan, Kenny Roberts, Kevin Troulé, Frederick C K Wong, Megan A Sheridan, Ilia Kats, Luz Garcia-Alonso, Britta Velten, Regina Hoo, Elias R Ruiz-Morales, Carmen Sancho-Serra, Jarrod Shilts, Louis-Francois Handfield, Luca Marconato, Elizabeth Tuck, Lucy Gardner, Cecilia Icoresi Mazzeo, Qian Li, Iva Kelava, Gavin J Wright, Elena Prigmore, Sarah A Teichmann, Omer Ali Bayraktar, Ashley Moffett, Oliver Stegle, Margherita Y Turco, Roser Vento-Tormo
Apr 17, 2023
The relationship between the human placenta-the extraembryonic organ made by the fetus, and the decidua-the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast...
Myometrium Decidua Organoids Stem Cells Trophoblasts Placenta Humans Transcription Factors maternal-fetal relations Cell Communication Cell Differentiation Cell Movement Pregnancy Pregnancy Trimester First Female Single-Cell Analysis Transcriptome multiomics
Published by: Nature